Table 3 Summary of selected published genome wide association studies in different canine tumors
From: Genetics of canine cancer: a guide for the veterinary oncologist
Author /Year | Breed (s) | Cancer | Lead SNP from GWAS | Genes highlighted as putatively implicated in disease risk |
|---|---|---|---|---|
Arendt 2015 [45] | Golden retriever | Mast cell tumors | US Chr14:11,765,081 EU Chr20:45,596,213 Combined Chr14: 11,721,433, 11,807,161 (equally associated) | Chr14: SPAM1, HYAL4, HYALP1 Chr20: HYAL1, HYAL2, HYAL3, GNAI2 |
Biasoli 2019 [49] | Labrador retriever | Mast cell tumors | Chr31:34,694,234 | Chr31: DSCAM |
Evans 2021 [50] | Flat-coated retriever | Histiocytic sarcoma | Chr5:33,001,550 Chr19:(conditional, heterozygotes for Chr5 lead SNP):52,487,724 | Chr5: PIK3R6 Chr19: TNFAIP6 |
Hayward 2016 [51] | Labrador retriever | Mast cell tumors | Chr36:16,889,272 | Chr36: ITGA6 |
Hedan 2021 [52] | Bernese mountain dog (BMD) Golden retriever (GR) Flat coated retriever (FCR) Rottweiler (RW) | Histiocytic sarcoma (HS) Mast cell tumor (MCT) Lymphoma (LSA) | BMD HS Chr11:41,161,441 BMD HS LSA Chr11:41,161,441 BMD GR LSA HS Chr5:32824053a BMD HS MCT Chr11:41,161,441 BMD GR HS MCT Chr20:33321282a BMD HS Chr11:41215628b BMD FCR HS Chr11:41252822b BMD FCR RW Chr11:41252822b | Chr1: RSPH3( other locus than lead SNP) Chr2: PFKFB3 (other locus than lead SNP) Chr5: SPNS3, TRPC6, BORCS6, Chr11: CDKN2A/B, CDKN2B_AS1, MTAP, CAAP1, TUSC1, C9orf72 Chr14: POT1, PSMD4, LEP, CPA1, Chr20: FHIT, ARHGEF3, IL17RD, C3orf67 ChrX: TBL1X, SHROOM |
Karlsson 2013 [13] | Greyhound (GH) Rottweiler (RW) Irish wolfhound (IW) | Osteosarcoma | GH Chr11:41,375,800 RW Chr1:113,616,670 IW Chr5:12,259,066 | Chr11: CDKN2A/B (Shared locus across breeds) Chr1: Multiple genes in this locus Chr5: BLID |
Karyadi 2013 [53] | Standard poodle | Digital squamous cell carcinoma | Chr15:29,371,013 | Chr 15: KITLG |
Labadie 2020 [54] | Golden retriever | T-Zone Lymphoma (TZL) Mast cell tumors (MCT) | TZL Chr8:53,818,371 (TZL) TZL + MCT Chr14:11794735a | Chr8: DIO2, TSHR Chr14: SPAM1, HYAL4, HYALP1 |
Letko 2021 [55] | Leonberger | Osteosarcoma | Chr11:39,434,964 | Chr11: CDKN2A/B |
Melin 2016 [11] | English springer spaniel | Mammary tumors | Chr11:73,290,522 | Chr11: CDK5RAP2 |
Mortlock 2023 [56] | Bullmastiff | Lymphoma | Chr33:8,104,361 | Chr33: SENP7, NFKBIZ, Chr13: MYC (other locus than lead SNP) |
Parker 2024 [48] | Shetland Sheepdog (SS) Multiple breeds | Urothelial cell carcinoma | SS alone and SS + multiple breeds Chr13:44,493,602, 44,508,476, 44,520,164 (SNPs equally associated) | Chr13: NIPAL1 |
Shearin 2012 [46] | Bernese mountain dog | Histiocytic sarcoma | EU Chr14:11,076,261 US Chr11 38,330,565 Combined Chr11:38,330,565 | Chr11: CDKN2A/B, MTAP |
Soh 2023 [57] | Border collie | Lymphoma | Chr18: 18:38,704,682 | Chr18: DLA79, Chr27: WNT10B, LMBR1L, KMT2D, CCNT1 (other locus than lead SNP) |
Tonomura 2015 [12] | Golden retriever | Hemangiosarcoma (HSA) B cell lymphoma (BLSA) | HSA Chr5:29,892,306 BLSA Chr5:33,845,636 HSA + BLSA Chr5:29,892,306 | Chr5: TRPC6, STX8 |
Truve 2016 [23] | Multiple breeds | Glioma | Chr26:9,780,187 | Chr26: CAMKK2, P2RX7, DENR |
Zapata 2019 [40] | Greyhound (GH) Rottweiler (RW) Irish wolfhound (IW) | Osteosarcoma | RW IW Chr1:1,136,161,670 GH RW IW Chr25:16,672,073 | Chr25: FGF9 shared locus across breedsa Genes nominated in other loci: CDKN2A/B, AQP4, OTX2, EWSR1 retrogene, BMPER, MTMR7, MARCO, NELL1, FBRSL1, IGF1, MTMR9, TANGO2 |