Fig. 3

Comparative oncology assessment of oHSV-M032 in dogs with spontaneous glioma. In this study dogs underwent baseline assessment inclusive of tumor imaging, clinical laboratory testing, immunologic assays such as serum cytokines, HSV antibody titer and HSV detection in saliva and peripheral blood. Surgical placement of the intracranial catheter with CT guidance is performed along with tumor biopsy, followed by a single dose of oHSV-M032. Monitoring of clinical and immunologic parameters follows at regular intervals until study exit. PE = physical examination, MRI = magnetic resonance imaging, CBC = complete blood count, HSV = Herpes simplex virus