Fig. 2

Comparative oncology trial schema for assessment of Cd200AR-L in dogs with spontaneous glioma. Confirmation of eligibility and baseline sample collections inclusive of brain imaging and immunologic correlates in peripheral blood were followed by craniotomy surgery for tumor resection and tissue collection. CD200AR-L combined with a tumor tissue lysate were administered via intradermal injection starting on post-operative Day 12 and continuing through Day 110. Dogs were monitored with serial imaging and clinical assessments along with immune monitoring until study exit. PE = physical examination, AXR = 2-view abdominal radiography, CXR = 3-view thoracic radiography. PBMCs = peripheral blood mononuclear cells, MRI = magnetic resonance imaging. Sx = surgery